Used as Peptide Reagents,Oligonucleotides Reagents.

DCI
1H-Imidazole-4,5-dicarbonitrile
Imidazole-4,5-dicarbonitrile (6CI,7CI,8CI)
4,5-Dicyanoimidazole
MOA 7
NSC 113954

1187-42-4
C4H4N4
DAMN
2-Butenedinitrile, 2,3-diamino-, (2Z)-
2-Butenedinitrile, 2,3-diamino-, (Z)-
Maleonitrile, diamino- (6CI,7CI,8CI)
(2Z)-2,3-Diamino-2-butenedinitrile
2,3-Diaminomaleonitrile
Diaminomaleonitrile
Hydrogen cyanide tetramer

4,5-Dicyanoimidazole(DCI) is used in the phosphoramidite chemistry. The phosphoramidite monomer, while it is stable in acetonitrile for weeks, is readily activated with DCI to form an intermediate which reacts rapidly and efficiently with the 5'-hydroxyl group of the extending oligonucleotide. The efficiency of this coupling step during oligonucleotide synthesis correlates directly with the final yield of product.

SECTION 1: GENERAL INFORMATION
Catalog Number(s): 30-3050
Common Name: 4,5-Dicyanoimidazole (DCI), Crystalline
Proper Name: 4,5-Dicyanoimidazole
Chemical Family: Substituted Heterocycle
CAS Number: 1122-28-7
M.W.: 118.1 Formula: C5H2N4
SECTION II: Composition/Information On Ingredients - % by Weight
• Active Component:>95% 4,5-Dicyanoimidazole, CAS Number:1122-28-7
• Other Components: Not available.
• Trade Names/Synonyms: None
SECTION III: Hazardous Identification
• NFPA Ratings (Scale 0-4): Not available.
• Emergency Overview: Harmful by inhalation, in contact with skin and if swallowed. Irritating to the eyes, respiratory system and skin. The toxicological properties of this material have not been thoroughly investigated. Use prudent laboratory practices for handling chemical substances of unknown toxicity.
• Potential Health Effects:
Skin Contact Short Term Exposure: Irritating
Long- Term Exposure: No information available
Eye Contact: Short Term Exposure: Irritating
Long- Term Exposure: No information available
Ingestion: Short Term Exposure: Irritating
Long- Term Exposure: No information available
Inhalation: Short Term Exposure: Irritating
Long- Term Exposure: No information available
Injection: Short Term Exposure: Irritating
Long- Term Exposure: No information available
• CARCLNOGEN/REPRODUCTIVETOXLN STATUS:
OSHA: Not Listed NTP: Not Listed IARC: Not Listed
SECTION IV: First Aid Measures
Skin Contact:
• Remove contaminated clothing.
• Flush affected area with water and then wash with soap or mild detergent and water.
• Observe for signs of irritation. If irritation is present, get medical attention.
Eye Contact:
• Wash eyes with large amounts of water or normal saline for at least 15 minutes.
• Observe for signs of irritation. If irritation is present, get medical attention.
Ingestion: Get medical attention.
Injection: If accidentally injected,get medical attention.
Note to Physician: There is no specific antidote. Treat symptomatically and supportively.
SECTION V: Fire Fighting Measures
FIRE AND EXPLOSION HAZARD: Not available.
SECTION VI: Accidental Release Measures
• OCCUPATIONAL SPILL: Wear appropriate protective clothing and chemically compatible &.loves. Place spillage in appropriate container for waste disposal. Wash contaminated clothing before reuse.
• REPORTABLE QUANTITY (RQ): Not Applicable

SECTION VII: Handling and Storage
• Observe all federal, state and local regulations. Do not breathe dusts. Avoid contact with eyes, skin and clothing. Wash thoroughly after handling. Keep tightly closed. Store in cool dry place. Use prudent laboratory practices for handling and storage of chemical substances of unknown toxicity.
SECTION VIII: Exposure Controls/Personal Protection
• Exposure Controls: Use in laboratory hood or other ventilated device. Occupational exposure limits for this substance has not been established by OSHA, ACGIH, or NIOSH. Use prudent laboratory practices for handling chemical substances of unknown toxicity.
• Eye Protection: Employees must wear splash-proof or dust-resistant safety goggles to prevent eye contact with this substance.
• Clothing: Employee must wear appropriate protective clothing (laboratory coat with long sleeves) and equipment to prevent skin contact with this material.
• Gloves: Employee must wear appropriate protective .-loves to prevent contact with this material.
SECTION IX: Physical and Chemical Properties
• Description: White to near-white crystals
• pH: Not available.
SECTION X: Stability and Reactivity
• Reactivity: No adverse reactions have been reported.
• Conditions to avoid: Avoid creation of dusts.
• Incompatibilities: Strong oxidizing agents.
• Polymerization: Not available.
SECTION XI: Toxicology Information
• Toxicity: The toxicological properties of this material have not been investigated. For research and development purposes only.
• Carcinogen Status: No information available
• LOCAL EFFECTS: Irritant.
• ACUTE TOXICITY LEVEL: No information available
• TARGET EFFECTS: No information available
• AT INCREASED RISK FROM EXPOSURE: No information available.
SECTION XII: Ecological Information
• ENVIRONMENTAL IMPACT RATING (0-4): No data available.
• ACUTE AQUATIC TOXICITY: No data available.
• DEGRADABILITY: No data available.
• LOG BIOCONCENTRATION FACTOR (BCF): No data available.
SECTION XIII: Disposal Information
• Observed all Federal, State, and Local Regulations.
SECTION XIV: Transportation Information
Ship as a non-regulated material. No transportation restrictions apply. The acute toxicity profile does not warrant shipment as a hazardous material (DOT) or a dangerous good (IATA).
SECTION XV: Regulatory Information
• TSCA STATUS: No • CERCLA SECTION 103 (40 CFR 302.4): No
• SARA SECTION 302 (40 CFR 355.30): No • SARA SECTION 304 (40 CFR 355.40): No

• SARA SECTION 313 (40 CFR 372.65): No • OSHA PROCESS SAFETY (29 CFR 1910.119): No
• SARA ACUTE HAZARD (CFR 40 370.21): • CALIFORNIA PROPOSITION 65: No
• CHRONIC HAZARD: No , - FIRE HAZARD: No,
• REACTIVITY HAZARD: No • SUDDEN RELEASE HAZARD: No
The information provided herein is based on sources believed to be reliable as of May 7, 2008 and pertains only to the material designated. Glen Research Corporation makes no warranty or representation to its completeness, accuracy,or currency. This material is intended for use by persons with pertinent technical skills and at their discretion and risk. It is the responsibility of the user to determine the product's suitability for its intended use, the product's safe use, and the product's proper disposal. Disposal of hazardous material may be subject to federal, state or local laws or regulations.